Breaking them off into particles, they get in a predicament
That be never reversible

from Tech N9ne (Ft. Busta Rhymes, Ceza, D-Loc, JL B.Hood, Twista, Twisted Insane, U$O & Yelawolf) – Worldwide Choppers Lyrics on Rap Genius

Meaning

A Chemical Change is a change that is irreversible caused by breaking up bonds between particles.
He is saying that his enemies will never be able to get out of the predicament he’ll put them in.

To help improve the meaning of these lyrics, visit “Worldwide Choppers” by Tech N9ne (Ft. Busta Rhymes, Ceza, D-Loc, JL B.Hood, Twista, Twisted Insane, U$O & Yelawolf) Lyrics and leave a comment on the lyrics box