I been gone too long and I'm down to lose it

from Game (Ft. Bun B, Chamillionaire, Clipse, Tha Dogg Pound, E-40, Fabolous, Fat Joe, Jadakiss, Ja Rule, Jim Jones, Juelz Santana, Lil Wayne, Nas, N.O.R.E., Rick Ross, Slim Thug, Snoop Dogg, Styles P, T.I., Twista, WC & Young Dro) – One Blood (Remix) Lyrics on Rap Genius

Meaning

Joe is mad at someone! But who?

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