Came back to annihilate to the game's in dire straits as I await

from Bad Meets Evil (Ft. Claret Jai) – Above the Law Lyrics on Rap Genius

Bad Meets Evil was originally created in 1999, so Eminem and Royce reuniting is the pair coming back to annihilate a (rap) game that is in dire straights (serious trouble.)

Basically, Eminem is saying that rappers these days are garbage and Bad Meets evil is resurfacing to destroy the unworthy competition.

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