I’m giving these hoes a dose of there own medicine
Let'em get a good taste of it

from T.I. (Ft. Eminem) – That's All She Wrote (Alternate Eminem Verse) Lyrics on Rap Genius

Meaning

All of the “hoes” are the other rappers, the ones that were tearing him down when he was on his hiatus, now that he is healthy he is tearing them down.

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