Hold up, talk to the, talk to the hand

from Big Sean (Ft. Kanye West & Roscoe Dash) – Marvin & Chardonnay Lyrics on Rap Genius

Meaning

What he’s saying is a part of the line “talk to my hand cause the face ain’t listening”.

If you don’t like what somebody is saying (a traffic warden, say) is to turn a palm forward and yell: “Talk to the hand"
He means that he doesn’t listen to the girl because what she’s saying isn’t relevant in the situation.

Also, Kanye has a fascination with the sitcom Martin and this was one of the show’s meme catchphrases

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