But I must be talking to the wall though I don't see nobody else

from Eminem (Ft. Kobe) – Talkin' 2 Myself Lyrics on Rap Genius

Meaning

Everybody thought he was done when he “hit the bottom”, nobody trusted he would come back.

He could also be using a double entendre, wall though or waldo saying he is singled out or alone like the book character “where’s WALDO”. It could also refer to the difficulty of seeing something that’s right before your eyes, like the idea you have to quit drugs.

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