, heavy problems
Genocide desensitized to violence
Makes it hard to sympathize
Harden,

from Lupe Fiasco – Ghetto Story Lyrics on Rap Genius

Synthesize means to combine or bring together. So lupe is joining the words genocide and violence which basically means the same thing, and saying that the violent black on black (genocide) crimes in the hood hardens one heart who’s heart is already small (miniscule) to feel to no sympathy for others. Thus becoming criminals themselves by embracing their violent habitual surroundings, as he would go on to say in the next line.

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