But don't let 'em say you ain't beautiful
They can all get fucked, just stay true to you
Don't let 'em say you ain't beautiful
They can all get fucked, just stay true to you

from Eminem – Beautiful Lyrics on Rap Genius

Meaning

Eminem even admits, though it is kinda corny, don’t let anyone else tell you that you aren’t a great person. Everyone’s special in their own way

This is also about the mentality he had to have in order to overcome all the obstacles that he was faced with. Had he not realized that he was talented he might not have ended up having as big an impact as he has had on rap and our culture in general. I don’t think this is intended as a pep talk to fans (or if it is, then that is not the only meaning).

Also, in the music video, kinda gives you the feel that he is talking to “Detroit” the city. Don’t let anybody tell you, you ain’t beautiful.

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