Painkillers, I call 'em cane pillars,

from Bad Meets Evil (Ft. Mike Epps) – I'm on Everything Lyrics on Rap Genius

Meaning

In the word “painkillers” Eminem switched the sounds K and P turning it into “cane pillars”. He explains why in the next two lines.

Switching consonants between two words in a phrase is called a spoonerism.

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