Niggas get to barking, put a bullet in the Great Dane

from DJ Khaled (Ft. Busta Rhymes, Cee-Lo Green, Ester Dean & Game) – Sleep When I'm Gone Lyrics on Rap Genius

Meaning

A double entrende by Game here:

Barkin' = talking smack and trying to front
Barkin' = the way a dog speaks
Great dane = a dog

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