F is for the family that’s holding me down
I think niggas know who run this town

from DJ Khaled (Ft. Fabolous, Jadakiss & Mary J. Blige) – It Ain't Over Til It's Over Lyrics on Rap Genius

The family Fab refers to here is not his biological one, but his crew the Street Family. The crew have been rumored to have been involved in actual street activities such as robberies of high-profile sports stars

Note also that the backronym stylings of this verse are a callback to Schoolly’s song

To help improve the meaning of these lyrics, visit "It Ain't Over Til It's Over" by DJ Khaled (Ft. Fabolous, Jadakiss & Mary J. Blige) Lyrics and leave a comment on the lyrics box