Mouth got cotton, prolly from the drugs

from Wiz Khalifa (Ft. Big Sean & Curren$y) – OTTR Lyrics on Rap Genius

Meaning

Smoking weed has been known to cause the smoker to get a dry mouth known as “cotton mouth”.

On the title track of Cabin Fever, “Phone Numbers” Wiz starts by saying he’s not blazing up like he normally does on the intro but instead drinking water, more than likely because of cotton mouth.

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