Holy water won't ward him off, crucifixes won't do the trick

from Eminem (Ft. Mr. Porter & Royce Da 5'9") – Westwood Freestyle 2010 Lyrics on Rap Genius

Meaning

Holy water and crucifixes are traditionally used to ward off demons or spirits; Shady is much, much worse and thus is immune. He’s a new, stronger kind of beast.

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