So refrain from the clap like a Prophylac
“The Clap” is slang for gonorrhea, a bacterial STD. Prophylac is short for prophylaxis which is when medication or precautions are taken to prevent an infection like gonorrhea.
So building off the previous lines, Wale wants people to stop clapping for him as if he needs it.
To help improve the meaning of these lyrics, visit "Samples and Shit" by Wale Lyrics and leave a comment on the lyrics box