If I lean out this window with Irene

from Lupe Fiasco – Failure Lyrics on Rap Genius

Meaning

People used to call their guns by female names so they couldn’t be traced (like how a 9mm handgun is referred to as a “Nina”), which also ties into the previous line (getting shot, put in the hospital, being on IV’s and respirator systems)

Can also be seen as a reference to the film with Jim Carrey Me, Myself and Irene as in Me and my Girlfriend like Tupac

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