We do this thug life shit, like 4, 5, 6, dick em'

from 2Pac (Ft. Outlawz) – Secretz of War Lyrics on Rap Genius

Meaning

4,5,6 is a reference to the game Cee-lo where if 4,5,6 is rolled the game is automatically over. Kadafi is using this a metaphor that if your not riding with them, your life is over, just how in game of Cee-lo is over once a 4,5,6 is rolled.

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