My uncle died, my daddy did too
Paralyzed by the pain, I can barely move

from Kanye West (Ft. Jay Z & Swizz Beatz) – Welcome to the Jungle Lyrics on Rap Genius

Meaning

Jay was shook up by the deaths of his uncle and father. Since he felt both of their deaths were directly or tangentially caused by the drug/street life, it made him hesitant to continue selling dope.

Obviously his quandary isn’t physical; Jay is not paralysed in the literal sense, but in a figurative sense he finds himself ‘paralysed’, unable to ‘move’ forward as he is unable to properly grieve or deal with the pain (this is connected to later lines in which he spells his out his tendency to hide his emotions).

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