I make moves, cause bowels to move
When I'm creeping through your way
With a thousand little dudes

from Big L (Ft. Jay Z) – 7 Minute Freestyle Lyrics on Rap Genius

Meaning

A heroin metaphor from Jay-Z. Thousand little dudes is referring to a key of heroin. Lil dude is a common street code for heroin. A thousand little dudes is obviously a thousand gram of heroin.

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