It's crazy how you can go from being Joe Blow
To everybody on your dick...no homo

from Jay Z (Ft. Kanye West & Rihanna) – Run This Town Lyrics on Rap Genius

Meaning

These opening lines presage a whole verse about what it’s like to become famous quickly, and how Kanye’s taken advantage of the fact that he’s done it.

What happened to the days when you could say things like “so many niggas on my nuts I thought I lost my dick” without having to plead “no homo”?

It’s also worth noting that Kanye is using the “no homo” trope just to set up the no Volvo joke: Kanye is on the record saying that rap is too homophobic and the use of “no homo” in a Kanye verse is completely out of character if not understood as a set-up for the joke

The phrase “Joe Blow” means a hypothetical average man. So Kanye is simply saying it’s crazy how you can go from being classed as average to being classed as super-star and having everybody on you and buzzing off you which in his terms is “everybody on your dick” The “no homo” bit was just him adding flair to the bar and setting up the line to rhyme with the next bar.

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