Facing the avenue
Back touching the wall, got the weed got the gun
Gotta run when I hear the bird call (Damn)
Hop in that thing and merk off, swerve off

from Lil Wayne – Hustler Musik Lyrics on Rap Genius


“Facing the avenue” refers to Wayne being on the street, dealing drugs. Wayne’s got the weed to sell and smoke, and he has his gun just in case and dangerous event presents itself. The bird call is the signal the cops are coming, so he drives off to avoid being caught by the police.

The “Bird Call” could also refer to Birdman. Wayne obviously looks up to him and respects him as a father figure, therefore Wayne would do anything for him if asked to.

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