What happened to religion? Oh, she lose it

from Kanye West (Ft. Rick Ross) – Devil in a New Dress Lyrics on Rap Genius

Meaning

“Losing my religion” is a popular phrase in Hip-Hop and American slang that means acting in a way that disregards general standards of social grace, civility, or morality (Remember the R.E.M. song?)

He sings the line in the rhythm of Wake Flocka Flame’s hook on “Oh Let’s Do It”, perhaps to mock the song’s pernicious message to the youth

He could referring to how girls could be very religious and abstain from sex, but when they meet Kanye they don’t care about that anymore — so they lose their virginity to him.

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