Cause this piff so potent, killing serotonin

from The Weeknd – Initiation Lyrics on Rap Genius

Meaning

The Weeknd is smoking high quality marijuana. He is also taking Ecstasy, which depletes the levels of the neurotransmitter serotonin in the brain which is a multi-purposeful chemical.

If there is a lack of its production, this can cause depression and alter digestion as well as mood. Many recreational drugs such as MDMA reduce serotonin levels and that reduction of serotonin after a heavy drug experience results in what is known as the “comedown” and the common feelings of depression afterward.

Heavy use of such drugs causes serotonin receptors to become inactive and ‘killed’, though some can be recovered through abstinence.

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