All you old rappers trying to advance
It's all over now, take it like a man
Niggas lookin like Larry Holmes, flabby and sick
Tryin to player hate on my shit, you eat a fat dick

from 2Pac – Against All Odds Lyrics on Rap Genius

Meaning

Talking about Q-Tip and A Tribe Called Quest; Q tip had talked shit about the West on the radio

He does look rather flabby and sick..

Also, as an ad-lib, after the “flabby and sick” line, he says “look at De La Soul”, dissing the whole Native Tongues movement.

De La Soul dissed Pac in a video, by imitating the “I Get Around” video, but Pac didn’t say anything. Then in 1996 they dissed Treach (Naughty By Nature member). Then Treach beat one of the members Del La up at a show and thats why Pac dissed them because they were going at Treach, who was one of Pacs best homies. All of it was really a misunderstanding.

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