It's fo'-twenty ho, now where the fuck is yo' weed at?

from Proof (Ft. B-Real & Method Man) – High Rollers Lyrics on Rap Genius

Meaning

You are supposed to smoke weed at 4:20, every day. You should have it out and ready the second the clock strikes it. Don’t be slow about it, or you’ll piss people like me and Method Man off. Also it is a reference towards this line on the song protect ya neck.

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