Tank on E, got no time to bump
So I'm running on fumes cause I live life once

from Mellowhype – Claustroflowbic Lyrics on Rap Genius

There are so many metaphors here. The big one is hes talking about his life in terms of a car. The tank on e is obviously empty gas, that’s why its running on fumes.

Fumes could also possibly be a reference to smoking marijuana

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