Used to see five-oh, throw the crack by the bench
Now I'm fuckin with five-oh it's all starting to make sense

from Game (Ft. 50 Cent) – Hate It or Love It Lyrics on Rap Genius

Meaning

Five-oh is normally police (from the police show “Hawaii 5-0”). In his younger years, Game would have to ditch his drugs when he saw cops coming

Now he’s dealing with a different “5-0”: 50 Cent. Things are starting to work out for him. The different associations he has now with the “five-oh” reflect his changed lifestyle and wealth: he used to be a street drug dealer just grinding and now he’s rich

“Sense” could be a play on words for “cents”, as in his relationship with 50 cent “has starting making cents”, for him, as he is making a lot of money off him.

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