First off: fuck your bitch and the clique you claim

from 2Pac (Ft. Outlawz) – Hit 'Em Up Lyrics on Rap Genius

2pac is saying “fuck you” to all of the people closest to Biggie: his bitch Faith Evans and his crew at Bad Boy Records (Puff Daddy, Lil Kim, etc)

“Fuck your bitch” has a double meaning in the case that Pac did, indeed, make love to Biggie’s wife as he claimed..

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