Uppers and downers I'm fuckin' with supplements under the counter

from The Palmer Squares – So You Think You Can Rap Lyrics on Rap Genius

“Uppers and downers” is the street slang term for stimulants and depressents (two different drug types). The phrase “under the counter” is used to indicate that he’s using over-the-counter drugs that you can buy at the store for purposes other than what they should be medically used for. In other words, he getting messed up.

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