Ayyo bust it, baby got a problem saying "bye-bye"
Just another hazard of a fly guy

from 2Pac (Ft. Digital Underground) – I Get Around Lyrics on Rap Genius

Meaning

“Ayyo bust it” is a common phrase in rap that means to get things started or to continue with equal or greater quality.

He’s flirting with other males' girlfriends, who have a problem letting 2pac go. But it’s nothing new. Just another everyday thing that happens to a fresh cat like 2pac.

The delivery of this line is accented with a laugh, which connects back to the previous line where 2Pac is being flirty and explaining that he wants his mistress to reciprocate.

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