That's why, Knowledge Of Self is like life after death
Apply it, to your life, let destiny manifest

from Black Star (Ft. Vinia Mojica) – K.O.S. (Determination) Lyrics on Rap Genius

Meaning

Having “knowledge of self” is like being reborn or awakening from being mentally dead, and by applying the “knowledge” obtained, its possible you could reach your true purpose in life.

Talib also makes a reference to Mos Def’s old hip-hop group, Urban Thermo Dynamics, which Manifest Destiny was their lead single for the album going by the same name, released 3 years earlier, in 1995.

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