Lost in this plastic life

from Kanye West – Lost In The World Lyrics on Rap Genius

Meaning

We live in a fake world, people are fake, their bodies, their personalities. Everyone is turning into a Barbie or a Ken. They call it “Plastic surgery” for a reason

Kanye’s mom died because of the complications of plastic surgery

Also a reference to the previous line: Michael Jackson was known for having skin issues, which some attributed to his frequent plastic surgery (rhinoplasty).

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