Knowing I can go, just switching a spare
On the highway of life, nigga it's sharp in my sight

from Jay Z – Intro Lyrics on Rap Genius

Meaning

Jay is well aware that he could die everyday due to the lifestyle that he leads, but he’s not afraid of that. His eyes are on the money, he wants to get rich and he won’t be distracted from anything.

Just switchin a spare on the highway of life” is a reference to Bill Cosby’s son who got killed in an attempted robbery on a highway in LA back in ‘97, he talks about him two lines later.

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