And my nigga Game light another L, pass the bottle
Pro-black I don't pick cotton out a aspirin bottle

from Game (Ft. Marsha Ambrosia & Nas) – Why You Hate the Game Lyrics on Rap Genius

Meaning

Nas and his homie Game is chilling smoking some weed and passing around the bottle.

Nas has shown numerous time he is pro-black through songs, interviews, documentaries, movies. Since he is pro-black that makes him anti slavery and asprin bottle used cotton so it´s still people picking cotton under hiddeous conditions. However some have stopped with it now.

Could also be a wordplay that being a slave to aspirin that can be addictive.

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