You can't stop the reign
When it starts to fall
There's no one else to blame
You can't unlock that door

from Shaquille O'Neal (Ft. The Notorious B.I.G.) – You Can't Stop the Reign Lyrics on Rap Genius

Meaning

You Cant stop the “rain” is the original saying but shaqs using “reign” as she saying when his rules “fall” under place, you cant doing anything about it, and its your fault your not strong enough to challenge him, you cant unlock the door to get to his level.

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