After the fire comes the rain, after the pleasure there's pain

from 2Pac – Killuminati Lyrics on Rap Genius

Meaning

With ‘fire’ to ‘rain’ he’s stating after violence sparks up (fire) there is a cool period (rain). With ‘pleasure’ to ‘pain’ he’s stating the opposite of the previous statement: that after living the high-life (pleasure) there is always a period of agony (pain).
This means both: 1.) Even though he’s in pain right now from their violence (‘fire’; him being shot 5 times) they’ll be a cool down period (rain) and 2.) His enemies will pay for what they’ve done to him, and even living good as they are (pleasure) karma will come around (pain).
He is also stating that he went through ‘pain’ (being shot 5 times) after living up the high life ‘pleasure’.

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