And shorty had no love for his sister
Cuz his sister would sniff up everything Jose gives her

from Juelz Santana – Lil' Boy Fresh Lyrics on Rap Genius

Meaning

Dealing with a loved one that is suffering from drug addiction can be difficult because it tests your love for them, and challenges your belief in that person. In this case, he has already lost his love for his sister who is a coke head getting her cocaine from Jose.

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