It's enough to make me just wanna jump out of my skin

from Eminem – 8 Mile Lyrics on Rap Genius

Meaning

“Jump out of my skin” could be just an expression of anger

Or

It would’ve been a lot easier for him to get accepted in the rap world if he was black, that’s why he wants to jump out of his skin. But remember Em, if you were black you would’ve sold half. Although even half would’ve still been pretty damn good.

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