"Hail Mary" to the city, you're a virgin
Play on the virginal status of Mary, the mother of Jesus, who was born without sin (with the suggestion that moving to the city will corrupt you); Jay Z “hails” (celebrates) the city’s darker elements.
One could also interpret “Hail Mary” as a last ditch attempt at success (i.e. a Hail Mary pass in football). In other words, a “Hail Mary to the city” could refer to the theme of coming to New York as an attempt for success despite the danger and risk that lies there.
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