Oh oh oh oh
Man I don't know what I'm gonna do
Without my boo

from Usher – Burn Lyrics on Rap Genius

Meaning

He doesn’t know what he is gonna do without the love of his life.

Two things:

A.) He wants his love back, yet simultaneously realizes he isn’t ready for a life without her, especially knowing he’s the one who messed up and tried to fix things too late (mentioned earlier in the verse). This pains him to think about, although with the tone of the hook of the song, he seems prepared to accept such a fate.

B.) A reference to another song on the album, “My Boo”.

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