Because I'm all about ends and skins
When you got those, you don't need no muthafuckin friends

from Big L – Lifestylez Ov Da Poor And Dangerous Lyrics on Rap Genius

Meaning

Big L does only care about money(ends) and womens(skins) because when you got a women to satisfy you, and money which you can buy everything with and which makes you happy, you won’t need no friends then. So he decided to murder he’s friend Chuck because Big L only care about money and womens. Just ask him;

The first line also sounds similar to his song No Endz No Skinz

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