Sign of the cross, cause this is her last suppa'
The Last Supper is a famous Biblical event, where soon after Jesus Christ was betrayed and crucified on the cross soon other.
You better make a sign of the cross with your fingers, because you won’t be gettin' a resurrection.
Metaphorical more than allegorical, Nicki’s saying her enemies' careers are going to end soon, like the Last Supper, so they better eat up and prepare to die, before it’s too late for them to back out from Nicki’s onslaught
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