I'm bill-dropping Ms. Pac-Man, this pill popping-ass ho

from Kanye West (Ft. 2 Chainz, Big Sean & Pusha T) – Mercy Lyrics 3 on Rap Genius

Meaning

Pusha’s spending mad bank so his Ms. Pac-Man can pop pills all night (Ms. Pac-Man gobbles up beads which look much like pills in her eponymous video game).

This could also be a reference to rapper Pill’s song “Pacman.”

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