Take an Excedrin

from Beastie Boys – Here's a Little Somethin' For Ya Lyrics on Rap Genius

Meaning

Ad is suggesting that listeners calm down, and if necessary, take a chill pill in the form of Excedrin. An over-the-counter headache/pain reliever, the primary ingredients in Excedrin are: Acetaminophen, aspirin, and caffeine. Excedrin developed market recognition for its commercials in which it resolved particularly uncomfortable and excruciating headaches.
http://www.youtube.com/watch?v=50AsPaM95vw

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