I was in too deep like Mekhi Phife
In that pussy so deep I could have drowned twice

from Kanye West (Ft. Big Sean, Chief Keef, Jadakiss & Pusha T) – I Don't Like Lyrics 1 on Rap Genius

Kanye is referring to the movie “O” when Mekhi Phifer and Julia Stiles are having sex and Mekhi goes too deep and starts to hurt her.

He backs this up with the very next line.

In the event of drowning in a pussy, the patented Weezy maneuver is always a viable option

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