Not the kind of nigga who major in something minor

from Jadakiss (Ft. Fabolous & Lloyd Banks) – Respect It Lyrics on Rap Genius

Meaning

In relation to the previous line about college, Loso always makes moves, all which are major and none minor ones: If he’s going for something, it’s something big.

IN CASE YOU AINT KNO SO, LOSO.

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