Nickname Medina make the seniors tote my Niñas

from The Notorious B.I.G. (Ft. 112) – Sky's The Limit Lyrics on Rap Genius

Meaning

“Medina” is a nickname for Brooklyn (Biggie was from Bedford-Stuyvesant — Brooklyn’s most dangerous neighborhood)

In Islam, Medina is the second-holiest city after Mecca — Brooklyn can similarly be considered the second holiest place in hip hop, spawning many of its greats (e.g. BIG, Jay-Z)

The holiest town for hip hop would be Harlem/the southern Bronx, where hip hop started…

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