I see my target, put my car in park and approach a tender
Young girl by the name of Brenda and I pretend to befriend her

from Eminem – Stay Wide Awake Lyrics on Rap Genius

Meaning

Slim uses a similar technique in one of the earlier skits on the album (“Tonya”), where he convinces a young girl that he is a good guy by giving her a lift while it is raining outside, then proceeds to duct tape her mouth shut and rape her.

By naming the “problem girl” in this situation Brenda, Em might be alluding to the 2Pac classic “Brenda’s Got a Baby”.

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