And the truth can be hard to swallow, depends on the size of the pill
And by the looks it’s about the time that you had your prescription filled

from B.o.B – Play for Keeps Lyrics on Rap Genius

Meaning

B.o.B is trying to explain that the truth can be hard to take. And also that some people need to see the actual truth.

He also implies that because of that true somebody (more precisely a hater) will be taking pills to just ignore it or not be depressed.

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