Jesus turned water to wine, I turn liquor to ur-ine
In addition to the obvious meaning (he drinks liquor and pisses it out), eXquire essentially labels himself the opposite of Jesus.
Jesus upgraded something positive like water to wine (which has many religious uses) while eXquire downgrades something negative like liquor to urine.
Also he picks up off the religious theme of El-P’s “Hark hear the archangel calling?” line.
To help improve the meaning of these lyrics, visit "Oh Hail No" by El-P (Ft. Danny Brown & Mr. Muthafuckin eXquire) Lyrics and leave a comment on the lyrics box