Load up Dreddy van, hit the L.I.E
Niggas rapping, they be trappin, that's a L-I-E

from Smoke DZA (Ft. Domo Genesis & Schoolboy Q) – Ashtray Lyrics 3 on Rap Genius

Meaning

DZA uses one of our favorite devices here, the homophone. The first “l.i.e.” is the Long Island Expressway, while the second is spelling out the word “lie”

Possibly a subliminal diss at 2 Chainz, who has a song called No Lie in which he raps the following…

Name a nigga that want some, I’ll out rap his ass, out trap his ass…

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Load up Dreddy van, hit the L.I.E Niggas rapping, they be trappin, that's a L-I-E

Load up Dreddy van, hit the L.I.E
Niggas rapping, they be trappin, that's a L-I-E